AVONEX PACKAGE INSERT PDF

1. Package leaflet: Information for the user. AVONEX 30 micrograms/ ml solution for Injection. (Interferon beta-1a). Pre-filled syringe. Read all of this leaflet. Package leaflet: Information for the user. AVONEX 30 micrograms/ml solution for injection in pre-filled pen. (Interferon beta-1a). Pre-filled pen. Read all of this. Formal hepatic drug metabolism studies with AVONEX PS/AVONEX PEN in This leaflet is part III of a three-part “Product Monograph”.

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It may interfere with the results of some tests. Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir: These side effects are very rare. No cases of transmission of viral diseases or CJD have ever been identified for albumin. In healthy volunteers, peak serum concentrations are generally achieved 15 hours after an IM dose range: Your doctor will recommend an injection site suitable for you.

If it is incomplete there is ‘progression of disability’. Yellowing of the skin and eyes also called jaundice. Cases have been reported several weeks to years after treatment initiation.

It should be colourless or slightly yellow. Do not push down on the injector shield and the blue activation button at the same time until you are ready to give injection. Major Patients receiving lamivudine with interferons with or without ribavirin should be closely monitored for treatment-associated toxicities, especially hepatic decompensation.

It is important not to miss injections as this can affect the success of your treatment. Major Natalizumab should be used with caution with interferon beta because of the potential for increased risk of progressive multifocal leukoencephalopathy PML and other serious infections with combined use. Biologic response marker levels e. Furthermore, they state that there are lower rates of liver-related mortality in coinfected patients taking HAART, even in those with end-stage liver disease, compared with patients not receiving HAART.

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Some formulations of interferon beta-1a contain human albumin and are contraindicated in patients with albumin hypersensitivity.

If you are a female of childbearing age and are sexually active, avobex should use birth control during treatment with AVONEX. It is not known whether these events were related to the effects of multiple sclerosis alone, interferon beta-1a therapy, or a combination of both. You may not experience any of them.

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Cobicistat; Elvitegravir; Emtricitabine; Tenofovir Alafenamide: Lamivudine; Tenofovir Disoproxil Fumarate: The above list includes serious side effects that may require medical attention. Return to the regular schedule the following week. If a dose is missed, administer it as soon as possible. Hold Pen with one hand and using other hand, hold onto the injector shield grooved area tightly and quickly pull up on the injector shield until the injector shield covers the needle all the way.

If a dose is missed, it should be given as soon as possible. Administration of Avonex pre-filled autoinjector: Do not expose to high temperatures. Used to treat epilepsy prevent fits. Do not use external heat sources such as hot water to warm.

Attach the needle by pressing it onto the syringe and turning it clockwise until it locks in place. In addition, interferon beta may bind to a distinct receptor that does not interact with interferon alpha.

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Pull off the sterile foil from the needle cover. According pacakge the manufacturer, it is not known if interferon beta-1a is excreted into breast milk, and due to the potential for serious adverse reactions in the nursing infant, a decision should be made to discontinue nursing or discontinue interferon beta-1a.

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Concomitant use of ocrelizumab with interferon beta may increase the risk of immunosuppression.

Patients should be closely monitored for signs of hepatic injury and caution exercised when interferon beta-1a is concomitantly with other inserrt associated with hepatic injury e. Titrate patients to the full dose over a 4-week period using the Rebif titration pack, which contains 6 doses of 8.

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With help from another person, may rotate between thighs and upper arms. You may need medical attention if you get some side effects.

Cover exposed needle with Pen cover. Biologic response marker levels usually peak within 48 hours of dosing. After the injection, use gauze pad to apply pressure for a few seconds or rub gently in a circular motion.

The immunoregulatory effects of interferon beta include decreased expression of class II major histocompatibility complex MHC antigens, inhibition of Avoex cells, decreased expression of pro-inflammatory cytokines including interleukin IL -1beta, tumor necrosis factor TNF – alpha and -beta, interferon gamma INF-G and IL-6, and upregulation of interleukin, which is an immunosuppressive cytokine that inhibits T-helper cells INF-G and TNF release.

The effects of interferon beta-1a during labor and delivery are unknown. They are followed by periods of recovery.

Avonex Pen should be injected into the upper, outer thigh. Injection sites should be rotated with each packafe to minimize the likelihood of injection site reactions. Use the alcohol wipe to clean the skin at the injection site you choose and allow it to dry prior to injection.